Non sedating antihistamine wiki
Chemically, levocetirizine is the active levorotary enantiomer of cetirizine, also called the l-enantiomer of cetirizine.
It is a member of the diphenylmethylpiperazine group of antihistamines.
The addition of, or a dosage increase in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine.
In larger plasma concentrations, it may lead to toxic effects on the heart's rhythm (e.g. In the United States, Seldane was brought to market in 1985 as the first nonsedating antihistamine for the treatment of allergic rhinitis.
In these people, the drug reaches threefold highest plasma concentrations six to seven hours after intake, and has a half-life of about 89 hours.